Pasi janne biography of barack obama

          Obama staff members.

          Pasi A. Jänne, MD, PhD

           Targeted therapies in lung cancer, novel EGFR inhibitors, mechanisms of drug resistance

          Laboratory-based investigations of Targeted Therapies in Lung Cancer Our laboratory work focuses on studying preclinical models of lung cancers that harbor oncogenic alterations.

          Who did obama appoint to the supreme court

        1. The President announced his intention to nominate Geeta Pasi to be Ambassador to.
        2. Obama staff members
        3. Pasi Janne, M.D., Ph.D., a lung cancer specialist at the.
        4. And former special assistant and personal aide to President Obama.

          5. The main focus of our work is to understand how oncogenic alterations found in lung cancer lead to sensitivity of targeted therapies. Furthermore, we extensively study both model systems and patient derived tumors to uncover mechanisms of drug resistance.

          Through these studies we have been able to identify novel therapeutic strategies for patients with different genomic subtypes of lung cancer.

          Preclinical and clinical development of novel EGFR directed therapies The most common mechanism (found in 60% of patients) of resistance to EGFR inhibitors is the secondary EGFR TM mutation.

          The initial studies identified a second class of EGFR inhibitors, covalent or irreversible inhibito